Adv Geriatr Med Res. Compared to mice with the same body mass, naked mole-rats have a lower metabolic rate, higher homeostasis-maintaining activities, higher oxidative damage levels, but a longer lifespan. These observations have raised serious challenges to the widely accepted oxidative stress theory of aging, which suggests a negative correlation between damage levels and lifespan. Here, we introduce a simple theoretical model based on energy conservation and the oxidative stress theory. Employing the model and the physiological parameters of mice and naked mole-rats, we explain why naked mole-rats have higher damage levels despite their higher somatic maintenance efforts; why damage levels in naked mole-rats seem not to change over age; and how these factors concertedly result in a longer lifespan in naked mole-rats. Our results highlight the energy tradeoff between biosynthesis and somatic maintenance, and suggest that the rate of damage accumulation over age and the existence of a threshold of damage for death are the keys to solve the paradox raised by naked mole-rats.
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Grab your friends and watch as Wilbur, a clothes-loving mole rat with exceptional style, navigates the pressure to be just like everyone else. With tail-shaking tunes, empowering messages of individuality, and classic Mo Willems humor, this musical is sure to rock audiences of all ages. All authorized performance materials are also supplied by MTI.
Detective walks from icing surrendering shooter Gimpy, so his commander asks Adam to volunteer to spy him. Adam struggles with taking the assignment on gun-happy comrade Bane, whose jacket includes Armored car robbers vanish across from Yankee Stadium, so Lt. Busti dragnets the neighborhood, house-to-house.