Harper and max family magnification
Oesophageal adenocarcinoma, which arises from an acquired columnar lesion, Barrett's metaplasia, is rising in incidence more rapidly than any other cancer in the Western world. The aims of this work were to characterise the expression of c-MYC, MAX and the MAD family in adenocarcinoma development and assess the effects of overexpression on cellular behaviour. Semi-quantitative immunohistochemistry and western blotting were used to examine cellular localisation and protein levels. Consistent with previous work expression of c-MYC was deregulated in oesophageal adenocarcinoma.
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Harper and max family magnification. Video Details Share Comments 0. Duration: 8min 32sec Views: Submitted: Category: Trans Male. Link to this video. BB code. Thank you!
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A largely self-taught man in science, he is commonly known as " the Father of Microbiology ", and one of the first microscopists and microbiologists. Raised in Delft , Dutch Republic , van Leeuwenhoek worked as a draper in his youth and founded his own shop in He became well recognized in municipal politics and developed an interest in lensmaking.
Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from disseminated cancer cells DCCs that can remain dormant 1. Metastasis-initiating cells are thought to originate from a subpopulation present in progressed, invasive tumours 2. However, DCCs detected in patients before the manifestation of breast-cancer metastasis contain fewer genetic abnormalities than primary tumours or than DCCs from patients with metastases 3 — 5. These findings, and those in pancreatic cancer 6 and melanoma 7 models, indicate that dissemination might occur during the early stages of tumour evolution 3 , 8 , 9. However, the mechanisms that might allow early disseminated cancer cells eDCCs to complete all steps of metastasis are unknown 8.